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00:00:00
thanks very much for the well welcome so my name's sarah and
00:00:04
i'm i'm representing a company called fabrics and stuff but
00:00:08
i just wanted to thank you organise is for inviting me here today to present about some of our research and
00:00:15
um it's not really my first time to the digital health connects but it's also my first time to switzerland
00:00:20
and yesterday was actually my first time having recollect if i'm channel tonight correctly and i'm definitely
00:00:27
not gonna eat three days it it big so um what i wanted to talk
00:00:32
about today really i want to introduce you to the well out of three d. printing
00:00:37
in particular howl and it could revolutionise um
00:00:40
the wealth of healthcare and pharmaceutical manufacturer
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so before we start i'm gonna talk a story and we've just had lunch so i don't think you're gonna be falling asleep i hope
00:00:52
um the basic i wanna talk about the evolution of technology how are we i'm here today so
00:00:59
over the past few hundred years that was going through a series of radical transformation
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i'm known as industry revolutions so fast industry revelation i had and in the late
00:01:09
seventeen hundreds and it's where humans actually harness the power steam and water
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um well actually able to change the way that we communicate with one
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another uh the way that we could use and also transport goods
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the second industry revolution occurred about a hundred years later and it's where we were
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able to take let's go energy and start to mass produce gets and
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from them into that industrial revolution another hundred years later with the advent of electronics and i. t.
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we're able to automate production and actually become a lot more efficient
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at mass production but my that these first three industry
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revolutions focused on um producing more of the same thing so
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warm is kind of a one size fits all approach
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but now we stand on the brink of new industrial revolution to the fall off or industry four points there
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and it's where objects all around us uh becoming smart and there's
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actually a massive push especially especially within pharmaceuticals to and actually
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start to pass no lies um madison's personalise our treatments so
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actually the way that we have um produced madison's previously
00:02:18
is not sufficient for the drive size needed and um let me give an example say
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for example the the top putting process was introduced over two hundred years ago
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that's within the second industry revolution and it hasn't really updated or changed much since then okay maybe a bit
00:02:34
more efficient but still there's no major uh um revolution in the way that we manufacture top that
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so i think a technology that would really i'm kind of changed the
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the manufacture madison's would be three d. printing and um so
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three d. printing essentially is a technology that can um deposit material
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layer by layer to create objects of different shapes sizes
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and the benefit is that you can and create unique and complex objects
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which would not be easy to do by mass production techniques
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so it's already been and up taken within healthcare in
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general so especially within dentistry say these are and
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that's an example of some three d. printed braces so that the brand name is invisible line
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not sure if you've heard of it but essentially take a mode of your mouth and then every week they
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will three d. printer new brace i'm for you and because there are visible you can't see them
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it's also been used in tissue engineering research so um this is an image here which is i think pretty
00:03:36
cool of and a three d. printed and kidney also three d. printed yeah and sleep today she
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and it's also been use within medical devices and prosthetics so this is a passing lies to hearing aid
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which and actually three printing 'em is being used to mask customised
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hearing aids now for patients rather than um standard technologies
00:03:59
and every that fabrics and see potential it is in a three d. printing of
00:04:04
tablets which sounds quite futuristic right and the actually it's it's a massive reality
00:04:12
and says sebastian mention the f. t. a. um approved about first three deep into top that
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um a couple of years ago and actually where we see um three d. printing benefiting
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um from c. to cause is actually with impasse citation said the f. d. a. approved
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top that did it for mass mass production they took a standard three deep into
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and they made a big scale process they can produce many the same types of top that's
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now well fabrics and what we aim to do is try passing lies treatments instead
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so this is an image here of some of our top let's they've actually
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got madison inside days but we don't call them three deep into topless
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we call them friends that so you've had top lets you fat cat let's and now
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we're gonna have printed really improving common to cover in the next few years and
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so i was um was mention fabrics is a spinoff company um from you see elsewhere uh a relatively small startup
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and so with germany within the research and development phases at the moment say what i wanna share
00:05:11
with you today isn't the research we've done and some of the potential applications for the future
00:05:19
so and the main question i always get offices how do you three deep in the top and so to make a a
00:05:26
simple i'm because i like illustration i have come up with the
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three d.'s of three d. printing every week or so
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if we wanna make a a formulation essentially we always start off the fast the witches design
00:05:41
so um let's say we have an elderly patient who perhaps
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console of a normal um sighs casual a top that
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what we could do instead is design um using computer aided design software
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and or disposable formulation in that instance up that like a like a fellow
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and we essentially create a file which can be read by a three d. printer system
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so we know we want it to look like the next d. is develop so now
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what we want to do is make sure it's gonna perform um acceptably within human
00:06:13
so what we have to do is select that like correct exceptions and also this the crack printing type
00:06:22
and then the final d. is dispense so the three different is that we have it
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fabrics are actually very very small you can that you pick one up and
00:06:31
but it where you want essentially so how we see it is perhaps we could
00:06:34
take a three d. printer but in within a hospital or community pharmacy setting
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or even in kind of within hard to reach areas to enable on site front
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no production and always right in front of the patients very are if
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and really as i mentioned this and drives the use of past nice medicines so
00:06:54
that there is a need for personalisation i think everybody in this room would agree that
00:06:58
we all different we'll all different ages different genders on different medicines different disease types
00:07:04
so actually the way that we treat people why one size fits all approach doesn't necessarily always work
00:07:10
no i'm not saying for a full madison's three d. printing would work for example for mass manufacture of power c. to model
00:07:16
it's never it's never gonna overtake that in terms of um cost effectiveness
00:07:22
but where it could help is in those satin patient populations such as the
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elderly or very young also in kind of complex disease states as well
00:07:32
and so i just wanted to go to some of the motivations full three
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d. printing so one of the main ones is around days flexibility
00:07:39
so conventionally as i said when we must manufacture topless will
00:07:43
produce thousands hundreds of thousands of exactly the same type
00:07:47
and the be fixed ranks fake shape fix colour fixed size fix released very far
00:07:53
and actually you that often leads patients having to maybe split top that so even crash and
00:07:58
way out how does to get their exact days that they need to which can be
00:08:02
pretty dangerous on is um been shown that if you break satin top let's then
00:08:06
it'll maybe effectively nice profile we might not be get an exact x.
00:08:13
and so and so okay and say with three d. printing you cannot she one of the benefits as you can
00:08:21
to pause a set amount of material so you can change the days based on the shape and size
00:08:25
so this is an example of one of off three d. printer is actually it was um developed previously as a um
00:08:32
candy printer so we're collaborating with magic candy factory and what
00:08:36
we're doing is we're developing formulations impinge up within it
00:08:39
so what you just so on the video is the pharmacist had a truckload it's a range
00:08:43
she's incest into the three d. printer and now you can see this range had to be
00:08:49
pushed down and out the other end is um the the material which has been deposited
00:08:55
and essentially these trait tuple top that cities are very acceptable
00:08:58
for um pediatrics and we're actually conducting a clinical study
00:09:03
at the moment in austin in spain which is using this um technology fall and treatment of a right disease
00:09:11
so one of benefits especially with this technology is it's quite it's quite quick this is also another
00:09:16
question and we always go how how long does it take so um with this um particular
00:09:22
extrusion based technology we can print we printed that you tablets in around eight minutes and which
00:09:28
okay compared to mass manufacture isn't very very quick but for personalisation would um be sufficient
00:09:37
okay it's the second motivation would be around essential lies production
00:09:41
and so as i mentioned that quite compact you can put it in whatever location that actually you want and
00:09:47
even we've and conceded taking a three d. printer not you put in up in space so and
00:09:53
nasa actually had um one of our um academic papers on the table and we were a we've been
00:09:59
in communication with them essentially to um try and start three d. printing methods medicines and space
00:10:05
and also kind of it in hard to reach areas had disasters owns um waugh ami counts
00:10:11
um but they don't really ah ah m. i. where we see the may
00:10:15
benefit been is within pharmacy and within the host one community sectors
00:10:21
suicide is around patient centred design so one of the benefits is that you can
00:10:26
choose the shape the size the coloured the taste so if your son
00:10:31
wanted his medicine to be a purple dinosaur which tasted like lemon and how
00:10:36
to paint i we could we could um we could theoretically do it
00:10:41
um so essentially it's around trying to make um taking medicines more acceptable
00:10:46
um it's about designing the medicine for the patient rather than just given the standard one i assume that they can take it
00:10:55
and we actually tested this concept in and human volunteers so
00:10:59
one of the benefits of been a spinoff from university is that there are a number of students
00:11:04
q. um i'll willing to try all three deep into top that's um so it's actually what we did is we printed
00:11:10
tablets of different shapes and sizes i wanted to evaluate how acceptable they wear to swallow and also to handle
00:11:17
and that's what we found was that the doughnut shaped oh i'm actually really acceptable which we didn't
00:11:22
and we didn't relies and also the normal happen and um top shape where as well
00:11:30
okay and finely and you can create these unique and complex dosage forms using three
00:11:35
d. printing so i'm just gonna give two examples because of of time and
00:11:39
and um essentially so with the elderly population amplify on c. can
00:11:44
be i must the problem so it's defined is taking more
00:11:48
than five medicines but myself as a pharmacist i have wants
00:11:52
to spend twenty eight different medicines for the same patient
00:11:56
so that's a minimum of twenty eight different formulations they're gonna have to take
00:11:59
it day a minimum and and this can become confusing i mean
00:12:03
if i was on twenty medicines i won't be able to keep track and um essentially with three d. printing what you can do
00:12:10
is that she and dispense more than one jerk into the same top let's say this topic here
00:12:15
is a um madison which has four different anti hypertensive this in and they're clinically relevant basis
00:12:23
and um it's actually we see this in um something tell madison's acceptance in the future
00:12:30
you can take it a step further you can even personalising forty files
00:12:34
so if you german offering a german flat his spanish different spanish fly i'm sorry i
00:12:38
haven't i haven't done this slide yeah the next time performance i promise i well
00:12:42
and also we're we're kind of struggling to make the u. k. and us save a you know watch watch this space
00:12:52
okay another example i want to give you was of um we can create really fast dissolving topless now
00:12:59
i'm not sure if decisions much to you but me as a formulation scientists
00:13:02
is super exciting okay so and essentially what we've done is the the
00:13:08
image on the top right is our three different to top that some because
00:13:11
the technology we've only got loose particles almost just superficially pound together
00:13:16
what that means is when you put it in a few minute walk to it just rapidly disintegrates and um
00:13:22
it's actually civil patient alternated it disintegrate very very quickly and the standard limits is it's three minutes to
00:13:28
be class doesn't already disintegrating top that we've done in two seconds think yeah it makes me excited
00:13:37
okay so there's gonna the the four main motivations and essentially um
00:13:42
we see this as i said being widely applicable to that patient populations yelling yeah on and
00:13:47
off the complex regimes and we hope to improve medication adherence efficacy and reduce side effects
00:13:54
so this is our vision okay i digital pharmacy era so
00:13:59
perhaps a patient will have a therapeutic need maybe
00:14:02
they will have um information about the blood pressure will
00:14:05
from certain applications we've discussed today to collect data
00:14:09
and um that data can be used to send to a a clinician you can create additional prescription
00:14:16
that could then be sent to um some these design that formulation and sent to a three d. printer and
00:14:23
then that um three even to get them past lies at madison be administered and the cycle repeats again
00:14:30
so this is our vision i mean it comes across a number challenges especially around um regulation
00:14:35
but as as a company we are talking to regulate agencies and trying to establish what requirements
00:14:40
uh needed from their side and what we can do um to help the facilitator
00:14:46
and find an overly touch net but i wanted to mention that i
00:14:49
know that this technology doesn't quite futuristic batches a reality in
00:14:53
is the news impact is um so ah sprees hand by preserve
00:14:57
pharmaceuticals as i said most manufactured reprinted top that so
00:15:01
there's more more research coming out every day sharon the maison opportunities that reprinting could bring 'em
00:15:09
so i sent you about were quite to come together and that's why it's kind of a plan should be in at this conference 'cause it
00:15:15
means i can talk to and many kind of people around the room
00:15:19
you and can maybe suggest different uh areas all different ways
00:15:23
that we could make this company uh successes actually um and i just wanted to highlight a couple of papers that we've written if you're
00:15:30
interested and around three depending pharmaceuticals and i'm happy for for any questions
00:15:35
and if you have any thank you for this thing and
00:15:44
no sorrow for the for the presentation
00:15:47
thirty question too forceful uh_huh look groups
00:15:54
you know it's like you for your presentation on your show some
00:15:58
warm body of three d. printer and we can you go
00:16:02
everyone use gonna be of our motion you know um you come you don't make drugs uh_huh so
00:16:08
all those who abuse is going to be regulated
00:16:12
by the country's uses the important question
00:16:17
one hundred percent is certainly an important question and so actually did to
00:16:23
anybody in this room could probably buy a three d. printer
00:16:26
and so what we're trying to work on as well is anti counterfeit matches so if um for example would
00:16:32
be we would reduce the top there and then transport that to a hospital for patient to take
00:16:37
and then used to be a way of ensuring that that probably is genuine that's somebody hasn't just manufactured it and and shit at that
00:16:44
and so that's kind of what we're working on and we were using kind of non invasive tools to try and do that
00:16:49
also it's gotta come from the regulate tree side as well so
00:16:53
regulator agencies got to always in a way we regulate um
00:16:58
like the types of three printers that can be used for pharmaceuticals but also um as actually just to ensure
00:17:03
patient safety so i do agree with you i think it's it's a it's a major um challenge
00:17:09
little portion last fall uh_huh
00:17:13
just what what what is going to do both
00:17:21
low low low vision hold who preserved to
00:17:29
prison for instance results comparable to production
00:17:34
and so what do you mean so i mean it instead was ah okay like buses go
00:17:42
to to hold knew who the problem for some for instance was almost from from lucian
00:17:51
is yeah i know well it's it's i mean it's a risk isn't it but i mean with three different
00:17:56
is in general you can print for whatever you want but um i sent you that's nice be
00:18:01
a way of ensuring that that that time page anyway nite doesn't that contains right second so we've been
00:18:06
working on a tool which can um tell you how much of the job is within it
00:18:10
and how much of a sequence of within that top as well so it can farms and ensures patient safety
00:18:15
um before it would ever be administered so that's what we're working on as as a company as well
00:18:22
uh_huh and so i'm using inspectors topic methods essentially is is the device which has
00:18:28
a light it tells you about the composition of that top that you can
00:18:31
create a model in the sense that model tells you whether it's genuine of
00:18:34
fake and how much of each company out each component is within it
00:18:41
yeah well well well the idea is to incorporated in the three d. printer say these devices a very very tiny so we
00:18:47
would like to put one inside of three d. printer ink of a that is a genuine goes slower slow do
00:18:56
so of course both proposals for mo versions
00:19:05
so data security you mean all around the shows i was yes
00:19:09
only to be kind of security measures in place yeah
00:19:15
yeah so the idea is that somebody will will design and design the formulation kind of
00:19:19
on site if you see what i mean so that'll help design not there and then um
00:19:24
the send you don't be printed for the patient on the monster kind of a single
00:19:27
step process in the way rather than being designed also also be like a
00:19:33
pharmacist or dispenser would would design as they would be interested with

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Conference Program

Mots de bienvenue
Sébastien Mabillard, CEO | Swiss Digital Health
June 15, 2018 · 9:07 a.m.
214 views
Mots de bienvenue
Victor Fournier, Chef de Service de la santé publique | Canton du Valais
June 15, 2018 · 9:11 a.m.
302 views
Mots de bienvenue
Jean-Albert Ferrez, Président | Fondation The Ark
June 15, 2018 · 9:19 a.m.
117 views
Mots de bienvenue
Laurent Sciboz, directeur Institut Informatique de Gestion | HES-SO Valais/Wallis
June 15, 2018 · 9:24 a.m.
270 views
L'écosystème d'innovation ouverte du CHU Sainte-Justine: une grande communauté gagnante!
Kathy Malas, resp. de la Plateforme de l’innovation et des Fonctions des maladies chroniques et aiguës | CHU SAINTE-JUSTINE (Canada)
June 15, 2018 · 9:33 a.m.
399 views
Les livraisons par drones : vers une amélioration de la logistique dans le domaine médical
Janick Mischler, Program Manager | LA POSTE SUISSE
June 15, 2018 · 10:07 a.m.
101 views
E-health et intégration des soins
Marc Cikes, CEO | MEDBASE ROMANDIE (Suisse)
June 15, 2018 · 10:32 a.m.
460 views
Patient empowerment in the digital age - Description and interest of an international online community of patients: Carenity
Remi Gauchoux, Business Development Director - Carenity
June 15, 2018 · 11:26 a.m.
122 views
Questions réponses
Remi Gauchoux, Business Development Director - Carenity
June 15, 2018 · 11:46 a.m.
135 views
Futur de la santé mobile
Dr. med. Patricia Sigam, CEO & Co-founder, digital Med-Lab
June 15, 2018 · 11:54 a.m.
212 views
Democratizing Data-Driven Medicine
Tarik Dlala, VP Marketing, Sophia Genetics
June 15, 2018 · 12:14 p.m.
511 views
Ada inside
Vincent Zimmer, Ada Health, Berlin
June 15, 2018 · 12:39 p.m.
596 views
biospectal, the optical revolution in hypertension monitoring
Prof. Patrick Schoettker, CMO. Biospectal
June 15, 2018 · 2:06 p.m.
1003 views
3D Printed Medicines: A Digital Pharmacy Era
Sarah Trenfield, MPharm, Senior Formulation Scientist, FabRx Ltd.
June 15, 2018 · 2:23 p.m.
444 views
The Digipharm experience
Ahmed Abdullah, CEO & co-founder, Digipharm, Basel
June 15, 2018 · 2:45 p.m.
3519 views
Enabling the rehabilitative revolution
Dr. Manfredo Atzori, HES-SO Valais Wallis
June 15, 2018 · 3 p.m.
242 views
Team Gamified Multi-sensory Stroke Rehab
Jean-Luc Turlan et J-P. Ghobril, Lauréats Arkathon 2018
June 15, 2018 · 3:22 p.m.
318 views
Secure and Trustable EMR Sharing using Blockchain: Open Challenges and Lessons Learned
Alevtina Dubovitskaya, HES-SO Valais-Wallis
June 15, 2018 · 3:38 p.m.
204 views
Conclusions
Sébastien Mabillard, CEO | Swiss Digital Health
June 15, 2018 · 3:59 p.m.
144 views

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