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and we're going to defy surprises and it's a privilege for me to have um
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the hundred to give the by matter award and to i'm a member of the parameter come
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a foundation and so i can give them but not to award two thousand and seventeen
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and the surprise he's going to lose time and to anita totem on
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there will be a lot of research work on then brain development on ice fix yeah and on
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them out of thirty and i'm very happy for her very weird on any type thing
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but there is no but not a whole lot without the but not a lecture
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and this lecture is very well structured since we have to i don't know what we can you
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develop this structure is a few years ago when he was the president of the foundation
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this is a lecture louisa lost in for exactly
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nine minutes three minutes for medical students three
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minutes for clinicians and three minutes for research so any thought that to you okay
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so thank you so much i'm i'm very one or two and uh
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it's it's a great a pleasure and i would like to thank
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of course all the committee who choose me and uh oh
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it's uh
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re station and and uh and the gift after all these years so it's it's quite
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and achievement in the career to get such a price but i have to say uh
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also for the other candidates that uh maybe sometimes it's
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a little bit of luck and just uh the good moment and the good person and
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uh i hope the other ones will have to look to see
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so when i came here this morning to see just a little
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story um i realised that exactly twenty five years ago
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i was here in this room it was open here and it was the e. c. f. and g. text
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so i was stressed at that time you know what is the c. f. n. g.
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it's the american exam and that's once i started my tree in my dream
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of being an academic noon that'll adjust so for those who know me
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it's not a has it for the other ones you maybe think it uh_huh
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so i once or
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so i have three minutes for the students i will give
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them in french i have three minutes for the clinicians
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and i have five minutes for the research
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so i uh and tied my my um
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just to do um my lecture protect the new ron's the challenge
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of then you're not all the just and the research
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um that's sixteen near enough that that eighteen conditional save their key
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to shoot one eight two four and then it starts
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it emerged more but well i'd flap effective is fuchs yeah you
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could make a sticker that's you don't sell secrets you
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oops
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uh in a gem of bodily doesn't that's the keys l. p. e. still take domestic senior natasha
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maybe it was you know the best to keep clean eek tree a dozen perspective do cash
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s. t. c. l. s. is just to fall in baghdad you look see
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i i in yeah yeah the the skinny at least do installs
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just go back to what distance yeah um i don't know i speak t. v. still expected
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that this sounds of well secure little when amy can not but a lot of yeah
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will will do you good job in when you make a kennel but that will only send it out
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this is used to listen to christian school three protect is and it's just a a
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um no over ah of wow huh uh you know you never want to how fat
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you know when they only would last it's you know shores more that the mighty
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a polite if they don't see now the you put down me to happy t. i. do s. boxes off
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i'll let you see now that that it either on or in um
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uh in problematic too salty uh p. b. to measure a high priest or a a
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focus not on people more general kept me you know do they stay behind
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on our streets in a in a uh also we should move on their own people do i can't call for
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a move when it at am best sixteen unit than the honey also ease
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sample packet for trips and a um don't all the way in
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the only uh problems it will be good to get your than the than winnie the
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mom yeah that that steve on top of course all say uh uh the
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the the move when they actually mel don't look at the last it's a state dump optimistic i must
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admit it l. v. we l. e. d. four accused only pay yeah i'm too scared easy
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may a landmark between older she if he calls the calls
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pulses awful when you've will option intimately side by
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when evil what are more time if i don't know most also yeah so uh again what is it
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lou for two c. v. tells them mm mom does are not given more epochs eek
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men sleeve was should set a foot to you later epochs each
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test it on cloud i i'd have no interruptions um a
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would you want to pull all those that was sounds about the uh
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evaluate don't that cannot divest get cut back on the like at the proxy
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a lot and it's also if that's about the only yeah let's see
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uh it call lee yeah that that's almost asleep by the time all uh uh come come oh
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it is all cease affair the problem and per study is this war
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these huge us your time i teach to proceed only couple the
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decoder more press out there due to reconvene back so
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yeah was you've known samples all this se seen unit that you know can cool
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yes much dish uh that simply nigger uh and pay him one tiny uh i knew file
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for standing fun not and even as a yet strangely outlined
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yeah but i must i mean people than i don't fancy kinds you can china shaft vocal plano was
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uh but i know i know i tune contemplates leash contests so
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i know for time practicality here just to take a um
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easy yeah to to give light light minded trained done here
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i introduced yeah for time in a a
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classy
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should be a a fertile and a trace that
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its contents yes yeah it's what i'm not for insects you
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asking type up go off and we'll do we'll do
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can get if they i mean me at how to pull mono in uh the atlanta who
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put tell me is that just as as can did not have that in nineteen
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the entire venues contests with a two stage won't exist explain blasts to compete and it once was you
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that's not a problem for not time
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not on hard to boss up they assumed was up i've yeah
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that's into goofy a city of ten and one fellow from
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in the fairfield what's and they're a strong much often uh how often
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does the uh goofy say this huge yeah target site so
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um what do you think if it's taken and the event yeah a
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couple of a and discuss what a fork on as a hoop
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to be yeah what does it stand for doubt as to uproot that's
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done uh that you just can't teach their janelle extending yeah
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yeah i know placenta which isn't a goofy is intact or does is deep lights
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and stuff and not some want to use it in c. for like
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she yeah i knew to be at a ski face as the skin tight it i'm in him a partition shock
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want a of fun to just pacman i see launch of touch
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rice i succeeded by the shop and that's pocket of that time issue as fixed yep and
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it's into his delusion past sixty plus i'm twenty i'm phones tries to go yeah i'm cool can
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i'm not going to be used to be able to wouldn't test a
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drastic c. to asked how to join keen tend to kind of
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movies check up to be as its cons clark done months each increase
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yet no one touches multicast seen you want me to focus
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when kinds long hot man and decent entertainment would make up by to be mine
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yeah me much to invest some unkind human uh and assignments our stuff even though it
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might need to be ends on mon and t. v. and vi i'm so mine
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sure it's a pretty common motion as these are these events and stuff and what and then uh uh
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good poked um manhattan game act as a um
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uh to kinda foolish and fun to evaluate and all that
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uh no location probably no harm for item no logo should probably not as a set
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da man get not get nasty should make the uh and to get some by speaker we class and now up to go
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that does and he does mind that stuff was the best time
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to conduct about pages to one incident seemed a bit yet
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i want to ask and demand on most on don't come down a a b.
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do i pull me to who put them into ted operator should be put to me right yeah you know what
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you more time it takes an encounter other i'll there's
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no solution of concepts and code orange um the
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as a as a scientist at the question of course is
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what are the fundamental questions and you heard about
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as income my cells you heard about uh uh and uh in the long run in
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the brain in the white matter injury uh so there are many ways to
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to uh uh to propose questions of course i have one question
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as a uh scientists is when i see the stammer
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here is an enter i have a very savvy or a stick to page would die
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what i see is this black lesions here in that talent
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was in the special nucleus of the taps and
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this new clothes is very sensitive to i sixty and to hike box and my question is how
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how is the new on dying in this in this um
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in this area so when i look at the histology i see i'm going excels like here you
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see in a big magnification you see that um the how i'm going make they are
00:12:05
going to die maybe programmed cell that men maybe not in when
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i look at other markers i find apocalyptic markers and i
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find out to fade to workers and that's the last a couple of die as a slides i want to show
00:12:21
is more for logically what are the different types of selfless well there is apple chose this
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macros is because this is eve or irreversible you cannot do anything probably
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will never do we will never have a treatment for the groups
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up to this the programs l. s. meaning that the cell get the information
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to die in one week to die in three weeks and then
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since the nineties there is another form of cell that's which is called will to fight age
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or all to fey g. excelled switches the type to twist described first
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by one of my mentors who was peter clarke in ninety nine
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and uh what is it actually it's some it's a it's a physiological um
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sell yes okay you her before by i think it it was the
00:13:11
first speaker um he told you that the new round half to to
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be cleared huh they die physiologically and they have to come back
00:13:21
so it's a recycling fabric that gets the new
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rounds and get some some uh energy back
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from the nuance to get it in a in a modern humans again into in order process
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so i cannot go into the details but they are different compartments or to fake was on auto lies
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and there are different types of uh to fey g. but i speak about maker who to fit each
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so what did my group using several models of in the evil in vitro
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and um and also human tissue we had
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uh access to adopt it to should we looked at enhanced also fey g.
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after high proxies kenya and what the role because if it's how right you don't know if it's good
00:14:12
or not so you want to know uh what is the role of the sort of thing
00:14:17
and i'm just going to show you one uh which was for me and i think
00:14:22
for our one of our best publications wasn't an ounce of neurology two thousand four
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we looked at brass rise spend which you model it's uh hypotheses
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kenya model and we looked at how to teach teach
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and what we see using specific markers uh of auto fey g.
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that in the racks or to fey jeez very much enhanced
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and in the u. t. should we had um i haven't babies
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five died from c. viewer is fixed yeah and six
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died from audio conditions all actor and we saw that oh
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to fate excelled as in the ten numbers with very
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a a much enhanced uh in this baby's around ten times
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and this somehow was called for in the demo right of three of the patient
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that show that the lesions where in the channels these lesions
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were seen early emma right on diffusion waited much
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so we could show in all the models that
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um oh to fade you was enhanced and that all in all the models that are
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in purple but of course in the human have not the answer that the inhibition
00:15:47
we tested several inhibitors that the inhibition was new or protect
00:15:55
so this is the end of my um my matter tool i would
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like to thank not down and his family he likes coldness
00:16:08
uh and he got a just a a little uh that's the state
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and he's very good very fine a despite his zero zero up go
00:16:23
i would like to thank my research lab and all the collaborators from a
00:16:29
a nationally but also internationally specially a soapy to clark and this guy
00:16:35
here it's not my collaborator but it's the nobel prize two thousand sixteen year
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she normally me who was a a nobel prize for to fiji
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and my mentor this is uh john mack weekend was physiologist
00:16:54
and magnesium specialist make um are you again
00:16:57
k. c. also never alleges magnesium specialist
00:17:01
no yeah they've all yeah but but don't put out she's onion at allergies from philadelphia
00:17:05
peter clark he with the fundamentalist and sell their specialist
00:17:10
and i really am missing out of course um hum
00:17:14
took me from burn too laws and and uh
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i was his first part time uh stuff uh comedy
00:17:24
stuff doctors so it was quite an achievement
00:17:28
and of course my boss and mentors office what does a could not attend i thank you for your change
00:17:43
actually i know simple who when you topple fit presenter
00:17:47
some fantastic only got this enough mutable doris
00:17:52
not about the little chip a city fussy no i don't

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Conference Program

Opening
Matthias Roth-Kleiner, Lausanne
Jan. 16, 2018 · 9:34 a.m.
377 views
Welcome words
Mathias Nelle, Bern
Jan. 16, 2018 · 9:36 a.m.
458 views
Personalised prediction of weight changes in the first week of life
Severin Kasser, UKBB
Jan. 16, 2018 · 9:41 a.m.
699 views
396 views
Neurofilament serum levels as biomarker of neuronal injury in very preterm born infants
Antoinette Depoorter, PhD Candidate
Jan. 16, 2018 · 9:49 a.m.
338 views
Neonatal red blood cell (RBC) transfusion practices in Switzerland
L. Gosztonyi, C. Rüegger, R. Arlettaz, Neonatology USZ
Jan. 16, 2018 · 9:58 a.m.
315 views
NEO (Neonatal Esophageal Observation) Tube - A feeding tube with monitoring function
Patrizia Simmen, Department of Neonatology, University of Basel Children's Hospital
Jan. 16, 2018 · 10:25 a.m.
571 views
Less invasive surfactant Application - Pro
Angela Kribs, Köln (DE)
Jan. 16, 2018 · 11:33 a.m.
1021 views
Less invasive surfactant Application - Contra
Sven Schulzke, Basel
Jan. 16, 2018 · 11:51 a.m.
1135 views
Q&A - Less invasive surfactant Application
Panel
Jan. 16, 2018 · 12:14 p.m.
314 views
Stem cells and birth
Martin Müller, Bern
Jan. 16, 2018 · 2:32 p.m.
671 views
Stem cells and white matter disease
Raphael Guzman, Basel
Jan. 16, 2018 · 3:16 p.m.
780 views
Protect the neurons: The challenge of the neonatologist and the researcher
Anita Truttmann, Service de Néonatologie, CHUV
Jan. 16, 2018 · 4:12 p.m.
541 views

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