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00:00:00
thank you thank you very much uh huh
00:00:02
francoise uh on our ah really age to be
00:00:08
and i hear these i don't know um so first of all we have
00:00:13
been known to ah everybody ah i
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thought you can see mine's alliance um
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and uh this time bomb the as a deficit over
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just mentioned uh use uh a term for
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on a um and went to view experiment ah
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uh that suggests that that that could be this isn't just to give factor
00:00:42
uh usually in a long correlation of
00:00:45
their bodies including days but also abrasion
00:00:49
or wine and the uh and the eh you know on call g. grass
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um this is the in a us one by me
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set our uh uh experimental investigations over the past few years
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a in the uh recently uh i do it is
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to be a little bit i has a layer star that
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um as you can see it um mostly in uh
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uh uh this little the intermediate stages uh and although
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definitions without slightly different uh across the the ones that is
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uh the the general uh i'm a ration how all understanding why yeah
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the only nation i'm all alone original generally
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particularly weekdays uh uh and uh you don't call
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don't know was able up to all the other i really gonna
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meeting world uh uh the the best which is you know all
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uh i was truly know where a is
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uh all of a sudden well uh raoul trials
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a combatant uh a few years ago um combining the they
00:02:08
the way the the parents trials there to uh use the combination oh okay
00:02:14
wow
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but even in the days later or randy need and ah there's all these uh uh it's that
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is really good to show um basically think i
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mean full band if you asses you will go huge
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no no reason why yeah i mean i know you didn't
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really unknown ones that he uh in this is they will
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this is a first i or a a foolish
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a a result a heavy in the red or the
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a very recently actually last small to uh and he also g. r.
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e. uh in this presentation a
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good said uh de uh uh ah
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comes uh all these uh face the around the nice the placebo controls
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that they uh all that they use a con man i mean do
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though we all we owe though but she's well asians we don't
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exactly lazy eligible for uh anyways
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h. i. who eventually i wouldn't bet
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so only to uh go into the d. a.'s he
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uh you know uh that pays a as the standard okay
00:03:33
uh for uh these asian population for more than twenty yeah
00:03:38
is uh we've and the problem as as i just change
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uh yeah in a uh several trials than uh than
00:03:47
that we rulebook be a ah consult days isn't it really
00:03:52
be a tendency oh two or a two or a cooler
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or progresses uh typically that yes uh i base the ah
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the the seven to eight miles uh uh
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in the best the report that ah it's so
00:04:12
that probably oh as that just a evaluate the the uh the as well as it is
00:04:19
uh to be able to use the tool or d. v. d.
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oh wait a recognition of the a.'s a
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a new job on the usual a the better
00:04:32
to age based on what they should uh it is uh as i say a small study well
00:04:42
i guess they j.'s easy easy so
00:04:44
patients arms legal or other for actually there
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section preservation of the initial null and it is all s. say ah
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these uh however as you can see uh asians when the and the
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all of eighteen they genre a soul will be wherever we do we yeah yeah
00:05:07
included in this than so only patients
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do you see any who or where excluded
00:05:14
this is a uh you know for
00:05:16
a a bit brackets to all other days
00:05:20
a while e. particularly in asia in
00:05:24
the stations bullish in them so uh generally
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about functional status the uh yeah are the usual our
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uh right okay yeah so he goes zero wow that
00:05:35
child a to be set basically see uh overall six
00:05:44
seven sixty pages where allows me to do yeah it's
00:05:48
so i'm i it was a bayes analysis blah blah blah
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follow i do ah i. n. the let's see well
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and he ah he was a day is the last
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two how old follow blah blah blah blah i bet
00:06:08
she's a lot and i will see he was it oh
00:06:12
groovy that they follow line plus d. pointed wall regressions resource
00:06:21
viable aura the yeah i don't know the use of the
00:06:24
combination oh wow and better she's one of the uh uh
00:06:29
advances that goes all the um he uses a library either
00:06:36
oh i'm sorry oh it's this slide shows
00:06:42
uh oh ah closer a a look today
00:06:48
uh s. ascii yeah so i'll uh oh just to maybe yeah ah
00:06:54
ah oh the balloon was meeting is that uh you show or the
00:07:01
uh uh uh where to the interface is the first page was a
00:07:06
bit racy you so well this was a a a a lasting ga
00:07:13
to see see lisa and you you get is a sixteen weeks huh
00:07:19
d. uh in the c. e. o.'s where are all the to the leader
00:07:24
a ah to four days a sound cool
00:07:29
tools uh when the number and it yeah
00:07:32
yeah and the e. c. or the
00:07:34
scratch a dual boa added as a
00:07:40
sly will start at uh at the work week that ah the the easy sure now
00:07:46
although the per se per states so the it's because it
00:07:52
is they see you as you can see there was no
00:07:55
i'll bet she's ah that any is there any any of
00:07:59
the cost in the second phase of the combination they use the
00:08:05
then uh uh this this phase that's
00:08:09
started that ah completion of the baseline calls
00:08:14
uh i you that he had a uh yeah we started it but we need
00:08:19
well we best she's about that or the right
00:08:22
about plus all's and then goody you down below
00:08:26
uh be your accessible doses e. or withdrawal
00:08:31
of cost of uh be before uh um
00:08:42
uh analysis as you can see and uh and they
00:08:46
can also play d. b. it finally f. s. analysis
00:08:52
is a a a all last analysis school your yeah and
00:08:58
he's uh i you know less than is this the last was
00:09:04
you can see if you can still be yeah why are uh
00:09:07
as that today is still on bowling go for the final and how
00:09:11
all always remains but ah that too in the c. e.
00:09:15
o.'s tend to be so it's here you ah v. e. um
00:09:22
this is actually there's a journey across uh the different uh we
00:09:28
then ah it's a and i see you can see a d.
00:09:34
uh alteration is received the uh one
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oh cool pays assigned pools uh and
00:09:41
this is uh this is the way the rhino sounds a little uh there was
00:09:46
a a fifteen to twenty percent of the patients who work uh received the previous
00:09:53
years uh uh uh or uh uh uh uh uh either for uh uh uh
00:10:00
basis i was usually pays you uh uh the number of
00:10:04
those are cool uh reach the b. combination a isn't as
00:10:09
well as the who's a a a sealer all the land
00:10:12
that i uh that that awful uh was there is interest ah
00:10:18
uh huh as you can see that is a
00:10:22
also consistency in their percentage uh all patients who
00:10:27
does still do you just definitely then that will
00:10:30
be useful division you do a lot of progress
00:10:36
it was a a named as a a worsening uh unconditional
00:10:41
investigations of the a. z. a city is uh that is uh
00:10:47
the school division will also work in the yeah the initial
00:10:51
about uh how ever jeez one but ah this is a d.
00:11:00
baseline carries fixed and the as you can see the patient populations why don't you
00:11:06
use solar flare and he gonna be eager to j. e. all of the day is the
00:11:12
bradley is and what decision eligible patients
00:11:15
uh a lot of ah go bad
00:11:19
relations e. dollars our legs are euro and the asia
00:11:25
uh as you can see you there was a light
00:11:29
blue twenty five uh uh twenty eight percent of the bay
00:11:34
d. c. s. c. stage a this is a a quite call i mean uh all the
00:11:39
base see it easily you can only a single words that or be part of the results are
00:11:46
i considered unsuitable uh for surgery
00:11:49
correlation uh some uh sixty percent also
00:11:54
way out uh yeah you can either stages that the
00:11:57
you know uh around fifty percent of the patients we yeah
00:12:02
uh d. c. and these stages see more costly as
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say the before uh he goes all uh or rainy days
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it was a a resin the you yeah i don't even mind knowing your beige good
00:12:15
talking about six seven santa observations uh where
00:12:19
already patients so bandied blanket we are sent that
00:12:24
our uh uh uh the uh what are kind of glass
00:12:28
says good uh yes they generalise the looking guy to barber
00:12:34
uh in there so uh the it's they're all the joel will uh um yeah animal
00:12:41
the way i'm a beige is a
00:12:46
a bowl the uh we you know
00:12:48
he up to seven great you together they're talking
00:12:51
about the around fifty percent of soul operations the uh
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uh we yes i think so yeah as well as uh you know that fifty percent to be on the
00:13:03
the absent variously basically they are the uh the visualisation reflect that
00:13:08
the uh essentially a bowl this
00:13:11
shenanigans alterations will really really either
00:13:14
to model or or extensive disease this is that really yeah well solo
00:13:24
designed shoulders the provisions result by
00:13:27
well over the combination uh all uh
00:13:32
as usual the end days versus a
00:13:36
a as well and it's uh as
00:13:40
you can see the course of a p. d. f. s. uh stats uh
00:13:45
uh i guess is that asian around the four fireballs
00:13:50
and that is the television is one day
00:13:52
that formula that don't last uh uh uh
00:13:58
and the the and that is is uh all well and eighty pounds
00:14:04
that is a a p. r. benefit associated with
00:14:08
the the a combination ah a really gave me yeah
00:14:14
yeah no i was uh i it onto i'll
00:14:17
see the placebo uh a call i must say that
00:14:22
uh and this is one of the best around or the the uh
00:14:26
uh and outcomes a full day is uh in this that you got
00:14:30
the law well our c. d. uh and is medium also proved that
00:14:36
binds six point eight balls uh obviously
00:14:38
you loans uh uh you the combination
00:14:42
uh the logo there that any days yes the visual was all that said he says you
00:14:52
you wanna be a and i uh analysis
00:14:56
oh oh yes as a use our rules as
00:14:59
uh and uh uh of course uh
00:15:03
somehow the psi rules are really these little
00:15:07
uh i i like the the uh the uh the
00:15:11
patients uh uh we yeah yeah so great yeah i
00:15:16
audiences okay yeah uh because uh as you can
00:15:21
uh this is to be a density in
00:15:26
bowl the this is that there is a little
00:15:29
as we leave it to beaver uh as well as well as as a disease
00:15:34
that in there is a or b. yeah it's uh this is enabling do we
00:15:42
what was the other person but uh i'm just few days go down the list
00:15:48
go air he bookcases sorry uh and this is the
00:15:53
the racial decreases viable uh assets in the uh in these
00:15:58
uh according to an analysis that instead all stand that
00:16:02
was is that uh we yeah therefore bowl k. e.
00:16:07
r. uh using deciding the standard with is the uh
00:16:11
the in a while so that it with brenda yeah point
00:16:15
this is crazy results are pretty consistent
00:16:18
uh and uh the uh the the
00:16:23
all the combination all who are lost their last days uh that's was a
00:16:28
placebo let's face is good for the you know yes uh_huh is also called ah
00:16:34
calling to address is only known for a while oh well that i use
00:16:42
all four uh i met a person's house see um as you can see uh
00:16:49
is the rule maybe yeah pass from eight o. two uh
00:16:54
two panels uh uh this was a sound that i belong there
00:16:58
uh in the uh for uh in this case the uh uh yes it was all
00:17:05
a statistic and the c. e. o. seven million oh it's a low the e. e.
00:17:14
the yeah the results all to you in the middle of our best that uh
00:17:19
that's placebo on the left uh and the in the middle of a model data
00:17:25
well all over ah one sees the the when the
00:17:28
results uh yeah yes enough for b. f. s. uh
00:17:32
uh so that was a statistically significant the drool that the e.
00:17:37
uh a big combination do you uh and uh and all this
00:17:44
and uh we were all that in their source
00:17:49
also uh the this is the yeah oversaw also calling
00:17:53
swallowing one the full stand ever sees the uh
00:17:57
uh responses ah yeah in one of our last bad
00:18:01
three percent of us was uh uh uh uh thirty percent uh our
00:18:05
bayes and all that again you see here is our uh uh cholesterol
00:18:11
this is one on one but i also will uh included a be a bit more
00:18:18
second only and all the uh all responses calling do and this is the probably more
00:18:24
a relevant to today's a shallow particularly for
00:18:29
patients undergoing a base for sea horses can see
00:18:32
a a response of four days a
00:18:36
hello although also a a whole speech
00:18:40
is that a soul yeah in line with the best of all it
00:18:44
all comes uh and it was kind of as a ah yeah uh
00:18:47
we've become a nation uh all the toolbar and uh that uh one
00:18:52
and two well this is the person had it's is it just see
00:18:55
yeah i went to the yeah the he want yours also
00:19:00
a a player whose father was is that we are talking about
00:19:04
all passionate pauses uh why when and where is this the uh
00:19:09
the commissioner who ah uh uh the best
00:19:13
uh and days the uh she the uh
00:19:17
as i say sixty percent the objective is also the the the person complete was false
00:19:23
uh uh which is a a or b. i. b. getting busy yeah also stage in
00:19:32
there so uh a delusional wings closer to
00:19:36
the little bottle all but you know the uh
00:19:40
uh uh uh given the longer you pass
00:19:43
the also useful was a bluegrass uh was
00:19:47
a alarmist uh he uh de uh and
00:19:52
live our last best the last days ah
00:19:55
uh s. b. a. loan yeah i was gonna see a lot so
00:20:01
this is not going to be a line though when you you guys say
00:20:05
and the the adverse events that uh uh as you can see uh
00:20:10
the asians in the combination ah a. c. yes the
00:20:15
a well yeah they the all the i say ease
00:20:18
a grey if war or a bus events the uh s. events the lee you
00:20:25
do these age uh all the that is the the way i don't know who uh
00:20:32
we don't know all that the uh i consider to be related to lately
00:20:39
yeah the a combination of logo and but you know that the ah intense all
00:20:47
uh mm really the medicines others that
00:20:52
is uh uh the profiles we are generally
00:20:57
no all
00:20:58
by unsolvable bob abilities bubble days as a uh as it
00:21:04
is even most all event the cross uh all the ah
00:21:07
this was the bottom one vision singles and our other verses ends are whether the whole though
00:21:14
uh uh adverse events associated with the grass the presentation or
00:21:20
a pretty you yeah i still in terms of lately for
00:21:26
uh yeah and then uh then we haven't all you or i mean is that
00:21:31
the the signals uh also the in this that i uh i don't want to do
00:21:39
the uh it's a budget and is is a whole range uh because this is yeah
00:21:45
it's not bad that uh is uh especially bowl on this i think all of us
00:21:51
uh the yeah combination blurb about but you know that
00:21:55
then without formations where the agree before um our age
00:22:01
uh for all this is that you have best is
00:22:03
a four one six percent that a rule the stations while
00:22:08
we would be slowly nation now the uh uh uh resoundingly there
00:22:13
when the whole uh uh a great file that because it would be a related to the man
00:22:19
that he uh the commissioner so we good i
00:22:25
yeah the uh um and uh well and uh
00:22:29
uh and that is fine and enable into so i
00:22:32
sat he's the pros a a global face regularly or
00:22:36
uh do the most the improvement but uh maybe for improving the f. s.
00:22:43
you don't data base that arrangement in the station what we
00:22:46
shall not all uh uh a little orange or lazy or
00:22:52
uh our second lazy individual for everybody's asian uh
00:22:57
the yeah yeah that was the evils as we're
00:23:00
in eight the old lawns uh all the control
00:23:04
i don't know any the vinyl though well also general
00:23:09
just and we don't know see profile although it she looked better
00:23:14
case it will allow the egg but she's also so this
00:23:19
i read in a seems one handy potential
00:23:22
to a a a change that i don't know
00:23:26
all three men wore a an original easy and you said the you
00:23:31
stand there okay uh of course uh no uh uh no uh uh
00:23:36
the asian is all really all the way the end that you couldn't
00:23:43
right yeah it isn't any evening and a bit is now uh and
00:23:48
then a jury trial uh on round the the code but i mean the
00:23:54
the the d. uh so i'm the the the better engine uh legally now
00:24:00
and then but ah versus stays is
00:24:03
uh the a and the uh um
00:24:08
really for the united states away yeah
00:24:11
uh one and the ease apparently invaluable
00:24:14
or option for you get me a beige is the uh uh and uh i
00:24:21
mean it was a random battles a windy over base so general one handy uh
00:24:28
we only a day is a that is a combination of blue and that uh
00:24:33
uh asses you we uh why i d. go
00:24:40
yeah that's i sometimes you thank you very much
00:24:50
i mean if you're gonna do for sharing his face every person competition for this
00:24:54
current really the first of this can probably would change the game we have one question
00:25:00
just wait for the microphone i presume it would thank
00:25:05
you very much and you're really impressive so study congratulation
00:25:10
mm women you really william lever surgeon using university hospital
00:25:15
yeah i have one question do you have the internet uh the the regarding
00:25:21
the possibility to achieve don't staging use p. shouldn't
00:25:26
i live in the to get access to recruit sprint to leave rejection
00:25:31
do you do you know what do you have it in b. shunning
00:25:33
records that come to find a you have enough don't speech into what
00:25:39
you were transparent yes yes i mean as you have seen a uh
00:25:46
probably lately the stanley a vision
00:25:49
is there a way at uh
00:25:53
i had to be a slew the probable see your second order one
00:25:58
and they ah or it could be a a hole where a and e.
00:26:04
yeah and they're uh you know following
00:26:07
a row a a a substantial down
00:26:14
is where the evil way either in the room who had
00:26:18
asians uh one eventually uh i see the recession of that
00:26:23
probably not allow ovations because of course uh as i say
00:26:28
it uh this was no no no the uh uh uh
00:26:33
a a a will probably we're both those on the um
00:26:38
these ah uh you know in a a secondary visitations uh
00:26:43
uh we don't and we had a um and they want no patients who received the
00:26:49
different walls so all three men uh uh
00:26:53
um any time or crash so uh uh
00:26:58
this is that anytime yeah let's say yeah announces that will be was that the
00:27:03
uh be independent last this means also we can uh which would be very difficult
00:27:12
to get the don't words of welcome right yeah really necessary to see the the
00:27:18
the effective to a therapy you give sorry
00:27:23
no i mean uh jumpers wind dash the
00:27:26
well we uh the most important of all right
00:27:30
so uh i'm i'm really uh uh we only
00:27:39
oh the air uh and then uh the only uh
00:27:45
you know we don't want to uh uh to uh or
00:27:50
will be usually bores over also via however you need only get
00:27:55
h. c. c. you combine and uh uh and he uh uh
00:28:01
the expense of uh oh that is currently uh probably in excess
00:28:07
all uh when he sees the most uh s. is the yeah
00:28:13
uh uh within the e. uh an additional
00:28:17
lines then and that outcome that but all
00:28:20
uh the only it looks like a learning curve for the or a phase v.
00:28:26
you can only guess they each uh uh we run it on
00:28:31
well i'm out we probably need a a to a really cool there
00:28:37
uh and then as i see me talking about thousands of patients
00:28:42
uh we'll probably get issue a discount yeah changes
00:28:47
and there and you may not be able to basically uh uh
00:28:51
you know be completely group so uh i'm gonna i see we
00:28:58
we you uh you get is a difference in the year uh
00:29:04
not just gonna one also or do you once in
00:29:07
a while longer than the lead one of reasons a or
00:29:11
b. you only yeah that would be a day uh and
00:29:15
all and that yes the u. s. is running oracle remedy
00:29:21
uh oh and then i think uh this will be
00:29:25
well known as a as a source once he had uh all the rubbish
00:29:31
i mean uh and all the the r. to
00:29:34
say uh uh uh uh formant video assess their the
00:29:39
uh brian will no no matter a
00:29:41
easy remains than conference you know a a
00:29:47
and b. e. d. while and balls are you know the all the next holes to
00:29:53
uh somebody be uh you're seeing
00:29:56
a a different the responses of the
00:30:00
year so so it's probably it's probably important to low angle is c.
00:30:06
well all the uh all the it or parliament
00:30:10
or just a a revenue reliable disease go out there
00:30:15
so this is why i i was present the
00:30:18
uh uh you don't respond to ah p. b.
00:30:21
uh and then usually run any and all the uh because because
00:30:26
of course the sounds are much more or less uh then uh
00:30:30
you know the tone of the show trials are coming back
00:30:33
to see all over also while not a reasonable so ah
00:30:39
once yeah design that just aren't overly and then uh then uh uh
00:30:47
there will be no guns monday the facts and i hear this equation is where all the
00:30:52
zero la yeah i uh uh uh uh uh the contribution our ass service uh
00:30:59
people don't do you no good for the the r. s. l. m. u. shoes on recommendations
00:31:05
uh once is the the only nice available
00:31:10
maybe it's a purse that is that it's very important for us that uh uh because for the first time as you
00:31:17
as you mentioned identity we're seeing all the
00:31:20
addresses i always the combinations i was the first
00:31:24
time that you see uh definitely uh antecedent than
00:31:28
be i'm going to learn of data is enhanced
00:31:32
uh probably will ah one b. where they stand
00:31:36
you know well well the rice the ball tennessee
00:31:39
a problem combination and and so so decides not over
00:31:44
um he grew uh we ah uh probably narrow the major
00:31:48
yeah i go in the manner by nationality there at this
00:31:52
point the uh you know for all across all the stages
00:31:56
daisy wheel uh from the uh really uh you amass a uh then
00:32:02
known as the uh and the stashing around you know whether to use a
00:32:06
uh a little recording age solves than that well thank you very much thank
00:32:13
you very much with the freezer thank you for your presentation incorporated him again

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Conference Program

Welcome
Jean-François Dufour, Berne
Feb. 29, 2024 · 2 p.m.
How to select systemic therapy for HCC
A. Saborowski
Feb. 29, 2024 · 2:05 p.m.
Recipient Prize
D. Martin
Feb. 29, 2024 · 4 p.m.
New Agents in Development for HCC
R. Finn
Feb. 29, 2024 · 4:30 p.m.
Closing Remarks
Jean-François Dufour, Berne
Feb. 29, 2024 · 5:30 p.m.