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the resident at the Department for unity
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Muslim and I'm very proud to present our
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current project here which focuses on
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the association of axonal injury in
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preeclampsia as you know preeclampsia is
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a main reason for preterm birth and
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early diagnosis and adequate treatment
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can prolong pregnancy and reduce
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morbidity and mortality related to
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prematurity the biomarker we looked at
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to show x to show external damage
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external injury was new development
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light chain which is a scaffolding
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protein of the news and no cytoskeleton
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and which is very important for growth
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and branching in then dendrites and
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axons it is a it is increase in cns xml
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damage and is a very reliable and easily
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accessible biomarker it is and it has a
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plasma CSF ratio from around 12 50 and
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is sometimes already elevated before the
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onset of neurological symptoms and since
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summer 2016 we have access to this
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unique diagnostic technique seymour
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which stands for a single molecule array
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in basel this is the study design a
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single cent of prospective study was
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performed at the university hospital of
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battle and enrolling pregnant women with
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high risk of developing preeclampsia and
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these data here were recorded blood
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pressure you're in sampling the blood
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sampling apart from our NFL from our
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biomarker angiogenic Marcus
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fleet and PF those are the established
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biomarkers to predict preeclampsia were
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measured and neurological symptoms and
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maternal and neonatal outcomes were
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recorded and inclusion criteria where
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pregnant women above the age of 18
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singleton pregnancy and patients at high
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risk for developing preeclampsia and
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exclusion criteria where fetal
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malformations these are the baseline
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characteristics and not surprisingly you
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can see that the characteristics that
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contribute to preeclampsia significantly
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elevated in the preeclampsia group
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compared to the control group we want to
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do know which factors have an influence
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on the NFL and NFL and used NFL as a
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dependent variable in a mixed linear
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effect model and we could show that
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maternal age and as flute which is the
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established biomarker to predict
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we're highly significant in this model
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gravity and neurological symptoms were
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significant and systolic blood pressure
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and lipstick were not significant in
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this model our findings were in this
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plot you can see and the work on the
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x-axis other age groups on the left side
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there controls on the right side of the
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women with preeclampsia and the y-axis
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you can see the NFL levels and we could
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see that the older the women were the
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high the NFL levels were with this
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roc curves with the red with the blue
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line standing for the NFL levels and red
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4s flute and green for Pele GF on the
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right side and this flood you can see
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the again on the y-axis the NFL levels
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and on the x-axis the different groups
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the different times of visits so the
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more the more to the right to further
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the pregnancy is and here again the
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further the pregnancy has elapsed the
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higher the NFL levels where and we
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conclude with this work that NFL
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increases with age and if l is higher in
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women with preeclampsia and NFL is
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predictive for preeclampsia and all the
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women and we explain this by adding that
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the NFL is increased and that indicates
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that the blood-brain barrier integrity
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is impaired tip thank you very much for